Kittens under 6 months old shouldn't be left alone for more than 2-3 hours. They need frequent care and supervision.
Healthy adult cats can be left alone for up to 48 hours with prep. Cats are independent but get lonely without company.
Older cats may need more frequent care like medication or litter changes. Limit time alone to 24 hours or less.
Cats with separation anxiety fare better with shorter alone times of 4-6 hours max. Consider pet sitters or day care.
Most cats can be left overnight, up to 10-12 hours. Ensure they have access to food, water, litter box.
For a weekend trip, have a trusted person check on your cat at least once, preferably twice.
Stock up on food, water, clean litter box before leaving. Give cats stimulation with toys, cat TV and more.